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Iatrogenic botulism is the most recent man-made form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and it may occur as an adverse event after therapeutic or cosmetic use.
Features include very common findings: Xerostomia, Ptosis, Orthostatic hypotension, and Muscle weakness and others; and common findings: Urinary retention, Constipation, and Dyspnea.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 4 | Difficulty swallowing (dysphagia), Cranial nerve paralysis, Fatigue |
Phenotype severity distribution: 10 very common features, 3 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for iatrogenic botulism.
25 publications have been identified in PubMed for iatrogenic botulism. Research spans Case Report / Case Series (60%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (16%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 15 | 60% |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Digestive system
2 |
Difficulty swallowing (dysphagia), Constipation |
Kidneys and urinary system | 1 | Urinary retention |
Eyes | 1 | Ptosis |
Muscles | 1 | Muscle weakness |
Lungs and breathing | 1 | Dyspnea |
5 |
20% |
Disease patterns and progression | 4 | 16% |
Laboratory research | 1 | 4% |
Van Horn NL (2026). [PMID: 29630230](https://pubmed.ncbi.nlm.nih.gov/29630230/). *Unknown Journal*. [Case Report / Case Series]
Easey S (2026). [PMID: 41947524](https://pubmed.ncbi.nlm.nih.gov/41947524/). *Internal medicine journal*. [Case Report / Case Series]
Shang R (2026). [PMID: 41701083](https://pubmed.ncbi.nlm.nih.gov/41701083/). *Foodborne pathogens and disease*. [Case Report / Case Series]
Dressler D (2026). [PMID: 41619021](https://pubmed.ncbi.nlm.nih.gov/41619021/). *Journal of neural transmission (Vienna, Austria : 1996)*. [Review / Meta-Analysis]
Jeffery IA (2026). [PMID: 29083673](https://pubmed.ncbi.nlm.nih.gov/29083673/). *Unknown Journal*. [Review / Meta-Analysis]
Fidancı H (2026). [PMID: 41546732](https://pubmed.ncbi.nlm.nih.gov/41546732/). *Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology*. [Basic Science / Preclinical]
Öztürk S (2026). [PMID: 41284652](https://pubmed.ncbi.nlm.nih.gov/41284652/). *Journal of child neurology*. [Case Report / Case Series]
An Y (2025). [PMID: 40289905](https://pubmed.ncbi.nlm.nih.gov/40289905/). *Clinical toxicology (Philadelphia, Pa.)*. [Epidemiology / Natural History]
Patel PN (2025). [PMID: 41103821](https://pubmed.ncbi.nlm.nih.gov/41103821/). *Cureus*. [Case Report / Case Series]
Jasperse J (2025). [PMID: 41040069](https://pubmed.ncbi.nlm.nih.gov/41040069/). *Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin*. [Epidemiology / Natural History]
AI-curated news mentioning iatrogenic botulism
Updated May 26, 2026
Recent research highlights Botulism Type F as a rare form of botulism that can mimic posterior fossa stroke symptoms. This discovery may aid in improving diagnostic accuracy for affected patients.
The CDC has released guidelines on preventing various types of botulism. These guidelines aim to enhance public health awareness and safety measures.
The CDC highlights actions that can elevate the risk of botulism, emphasizing the need for public awareness and preventive measures. This information is crucial for healthcare providers and public health officials.
The CDC provides an overview of botulism, detailing its causes and symptoms. This resource aims to enhance public awareness and understanding of the disease.
A study from a tertiary medical center in Taiwan evaluates the timeliness and diagnostic yield of suspected botulism notifications from 2014 to 2024. The findings may provide insights into improving diagnostic processes for this rare condition.